Byron Maxwell played college football at Clemson where he redshirted his freshman year to continue to rehab his knee. Byron Maxwell went on to have 27 tackles and four pass breakups his sophomore year, a team leading 15 tackles as a junior , and as a senior, while playing in all 13 games and starting eight, he had 48 tackles. Byron Maxwell played in four bowl games during his collegiate career and was known as being one of the hardest hitting defensive backs in the ACC.