He spent 2009 as a member of the Philadelphia Eagles’ practice squad. Amendola was signed by the St. Louis Rams where he played from 2009 to 2012. In 2013 he was signed by the New England Patriots to a five year deal worth $28.5 million with $10 million guaranteed. Amendola set a record for most receptions in the first half of an NFL game with 12. With the Patriots he won the AFC Championship in 2014.