Dominique Rodgers-Cromartie was selected with the 16th overall pick in the first round of the 2008 NFL Draft by the Arizona Cardinals. Dominique Rodgers-Cromartie played for the Arizona Cardinals for three seasons from 2008 to 2010 and was selected to the 2010 Pro Bowl though he was unable to play due to an injury. Dominique Rodgers-Cromartie played for the Philadelphia Eagles during the 2011 and 2012 seasons. The Eagles had him in the nickel position which he was not accustomed to and he had no interceptions during his first season in Philadelphia. On March 13, 2012 Dominique Rodgers-Cromartie signed a $5 million dollar, one year contract with the Denver Broncos.
