In 2008, Duke Ihenacho led the FBS in interceptions. During the 2009 season Ihenacho had 89 tackles, the second most on the team. Heading into the 2012 NFL Draft, Duke Ihenacho was considered one of the top strong safeties and a projected 5th round pick, however he went undrafted. The Denver Broncos signed Duke Ihenacho to the practice squad in September 1, 2012, activated him on September 29th, cut him on October 11th, signed him back to the practice squad on October 13th, put him on the active roster on November 1st, waived him on November 13th, and resigned him to the practice squad on November 16th, 2012. On September 5, 2013 Duke Ihenacho started his first NFL game Strong Safety for the Denver Broncos against the Baltimore Ravens and had 11 solo tackles in Denver’s 49-27 win.