He starred in the series Two Thousand Acres of Sky from 2001 to 2003. In 2003 Cusick starred as Miles Longmuir in the series The Book Group. One of his best known roles came as Desmond Hume in the television series Lost from 2005 to 2010. In 2012 he starred as Stephen Finch in the series Scandal and in 2014 as Kane in the series The 100. He has starred in the movies The Gospel of John and Jesus Christ, Half Light, 9/Tenths, Hitman, Not Another Happy Ending, and The Girl On The Train. Cusick was nominated for a Primetime Emmy Award in 2006 for Outstanding Guest Actor in a Drama Series for Lost. In 2006 Henry married Annie Wood and the couple has three children together.
