He played with the Falcons from 1986 to 1993. Dukes then went on to play for the Green Bay Packers in 1994 and the Arizona Cardinals in 1995. He retired following the 1995 season. In 2006 Jamie joined the NFL Network and worked as an analyst for NFL Total Access and NFL GameDay Scoreboard. He also contributes to NFL.com. In 2010 he was behind a grassroots weight loss campaign called the Billion Pound Blitz Initiative. He is also the host of the Atlanta radio program Middays with Jamie Dukes.