From 1999 to 2000 she starred as Charlotte on the television series Lucy Sullivan Is Getting Married. Letitia Dean has also appeared in episodes of the TV series Brookside, Relative Strangers, Casualty, The Bill, Drop the Dead Donkey, and Doctors. In 2004 she was nominated for British Soap Awards for Best Actress and Best Dramatic Performance. Dean released the fitness DVD Letitia Dean’s Lean Routine in 2009.