Anderson has appeared in several films including One Good Cop, Livin’ Large!, Trial by Jury, Clockers, Big Momma’s House 2, The Second Chance, Madea’s Family Reunion, Probably Cause, First Impression, and more. She has also appeared in episodes of the TV series The Cosby Show, The Practice, The Steve Harvey Show, Meet the Browns, Drop Dead Diva, Law & Order: Special Victims Unit, and more. In 2015 she won a Best Actor Award for The Sin Seer at the American Black Film Festival. Lisa Arrindell Anderson was nominated for Black Reel Awards for Network/Cable – Best Supporting Actress in 2000 and 2001.