He starred as General J. Luis Mendez in the TV series Infames in 2012. Marco made his feature film debut in 2012 starring as Amado in the movie Colosio: El asesinato. In 2012 Zetina starred in the TV series Capadocia as Cirujano and La Patrona as Marcelo Vidal. In 2013 he starred as Leonel Canseco in the television series Fortuna.