Rulli married his longtime girlfriend Cecilia Galeano on December 31, 2007 in a small ceremony attended by about thirty friends and family. They have son, Santiago, born January 15, 2010. The couple separated in 2011. He was then reportedly in a relationship with Mexican actress Aracely Arámbula. In July of 2013 he confirmed the end of a 16-month relationship with Aracely Arambula and was reportedly dating his Lo Que La Vida Me Robo costar Angelique Boyer. On June 26, 2013, it was confirmed that Sebastián Rulli (along with Angelique Boyer and Luis Roberto Guzmán) would star in Angelli Nesma’s Lo Que La Vida Me Robó, a remake of Ernesto Alonso’s Bodas de odio produced in 1983. In 2016 Sebastián Rulli co-hosted the Latin Grammy Awards along with actress Roselyn Sanchez.