In 2006 he had a recurring role in the series The Amazing Mrs. Pritchard. Mison has starred in the TV mini-series Lost in Austen and Parade’s End. He has appeared on episodes of Secret Diary of a Call Girl, Agatha Christie: Poirot, Lewis, Masterpiece Mystery, and New Tricks. Mison has starred in the films Venus, Heroes and Villains, One Day, Salmon Fishing in the Yemen, Jadoo, and Dead Cat. His best known role started in 2013 as Ichabod Crane on the Fox series Sleepy Hollow. He is nominated for a Teen Choice Award for Choice TV: Male Breakout Star in Sleepy Hollow in 2014. Tom married Charlotte Coy in 2014.